FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review.

ABSTRACT: FcRn plays a major role in regulating immune homeostasis, but it is also able to transport biologics across cellular barriers. The question of whether FcRn could be an efficient transporter of biologics across the nasal epithelial barrier is of particular interest, as it would allow a less invasive strategy for the administration of biologics in comparison to subcutaneous, intramuscular or intravenous administrations, which are often used in clinical practice. A focused systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. It was registered on the international prospective register of systematic reviews PROSPERO, which helped in identifying articles that met the inclusion criteria. Clinical and preclinical stud

SUBMITTER: Fieux M 

PROVIDER: S-EPMC8234196 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature