Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC8234244 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Yu Mingjia M Zhao Huimin H Miao Yuhui Y Luo Shi-Zhong SZ Xue Song S
International journal of molecular sciences 20210621 12
Immune therapy has emerged as an effective treatment against cancers. Inspired by the PD-1/PD-L1 antibodies, which have achieved great success in clinical, other immune checkpoint proteins have drawn increasing attention in cancer research. B and T lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) are potential targets for drug development. The co-crystal structure of BTLA/HVEM have revealed that HVEM (26-38) fragment is the core sequence which directly involved on the interfac ...[more]