¹⁸F-florbetapir PET/MRI for quantitatively monitoring myelin loss and recovery in patients with multiple sclerosis: A longitudinal study.

ABSTRACT:

Background

Amyloid positron emission tomography (PET) can measure in-vivo demyelination in patients with multiple sclerosis (MS). However, the value of ¹⁸F-labeled amyloid PET tracer, ¹⁸F-florbetapir in the longitudinal study for monitoring myelin loss and recovery has not been confirmed.

Methods

From March 2019 to September 2020, twenty-three patients with MS and nine healthy controls (HCs) underwent a hybrid PET/MRI at baseline and expanded disability status scale (EDSS) assessment, and eight of 23 patients further underwent follow-up PET/MRI. The distribution volume ratio (DVR) and standard uptake value ratio (SUVR) of ¹⁸F-florbetapir in damaged white matter (DWM) and normal-appearance white matter (NAWM) were obtained from dynamic and sta

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8234356 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature