Same salience, different consequences: Disturbed inter-network connectivity during a social oddball paradigm in major depressive disorder.

ABSTRACT:

Background

So far findings on emotional face processing among depressed individuals reveal an inconsistent image, with only some studies supporting a mood-congruent bias in salience processing. Thereby, many results are based on the processing of sad emotions and mostly focused on resting-state connectivity analysis. The present study aimed to target this misbalance by implementing a social oddball paradigm, with a special focus on the amygdala, the ACC, the insula and subdivisions of insula and ACC.

Methods

Twenty-seven depressed patients and twenty-seven non-depressed controls took part in a fMRI event-related social oddball paradigm based on smiling facial expressions as target stimuli embedded in a stream of neutral facial expressions. FMRI activation and functional conn

SUBMITTER: Koeppel CJ 

PROVIDER: S-EPMC8234357 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature