Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers.

ABSTRACT: Curaxins and especially the second-generation derivative curaxin CBL0137 have important antitumor activities in multiple cancers such as glioblastoma, melanoma and others. Although most of the authors suggest that their mechanism of action comes from the activation of p53 and inactivation of NF-kB by targeting FACT, there is evidence supporting the involvement of DNA binding in their antitumor activity. In this work, the DNA binding properties of curaxin CBL0137 with model quadruplex DNA oligomers were studied by ¹H NMR, CD, fluorescence and molecular modeling. We provided molecular details of the interaction of curaxin with two G-quadruplex structures, the single repeat of human telomere d(TTAGGGT)₄ and the c-myc promoter Pu22 sequence. We also performe

SUBMITTER: Dallavalle S 

PROVIDER: S-EPMC8234370 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature