Hsa-miR-605 regulates the proinflammatory chemokine CXCL5 in complex regional pain syndrome.

ABSTRACT: Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by inflammation and debilitating pain. CRPS patients with pain refractory to more conventional analgesics can be treated with subanesthetic doses of ketamine. Our previous studies found that poor responders to ketamine had a 22-fold downregulation of the miRNA hsa-miR-605 in blood prior to ketamine treatment. Hence, we sought to investigate the functional significance of miR-605 downregulation and its impact on target gene expression, as investigating target mRNAs of differentially expressed miRNAs can provide important insights on aberrant gene expression that may contribute to disease etiology. Using a bioinformatics prediction, we identified that miR-605 can target the proinflammatory chemokine CXCL5, which

SUBMITTER: Pande R 

PROVIDER: S-EPMC8234436 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature