Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma.

ABSTRACT: Available biomarkers for pancreatic adenocarcinoma (PAC) are inadequate to guide individual patient prognosis or therapy. Therefore, herein we aimed to verify the hypothesis that differences in the expression of KIF11 and KIF14, i.e., molecular motor proteins being primarily implicated in cell division events could account for the differences in the clinical outcome of PAC patients. In-house immunohistochemistry was used to evaluate the protein expressions of KIF11 and KIF14 in PAC, whereas RNA-seq datasets providing transcript expression data were obtained from public sources. IHC and mRNA results were correlated with clinicopathological features and overall survival (OS). Furthermore, the genes co-expressed with KIF11 or KIF14 were predicted and functionally annotated. In o

SUBMITTER: Klimaszewska-Wisniewska A 

PROVIDER: S-EPMC8234517 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature