Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy.

ABSTRACT:

Background

For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenerative disease emergence and severity. Numerous studies in animal models of amyloidosis demonstrated the beneficial role of monocyte-derived macrophages in mitigating the disease, though less is known regarding tauopathy. Boosting the immune system in animal models of both amyloidosis and tauopathy, resulted in improved cognitive performance and in a reduction of pathological manifestations. However, a full understanding of the chain of events that is involved, starting from the activation of the immune system, and leading to disease mitigation, remained elusive. Here

SUBMITTER: Ben-Yehuda H 

PROVIDER: S-EPMC8234631 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature