A conserved female-specific larval requirement for MtnB function facilitates sex separation in multiple species of disease vector mosquitoes.

ABSTRACT:

Background

Clusters of sex-specific loci are predicted to shape the boundaries of the M/m sex-determination locus of the dengue vector mosquito Aedes aegypti, but the identities of these genes are not known. Identification and characterization of these loci could promote a better understanding of mosquito sex chromosome evolution and lead to the elucidation of new strategies for male mosquito sex separation, a requirement for several emerging mosquito population control strategies that are dependent on the mass rearing and release of male mosquitoes. This investigation revealed that the methylthioribulose-1-phosphate dehydratase (MtnB) gene, which resides adjacent to the M/m locus and encodes an evolutionarily conserved component of the methionine salvage pathway, is required for s

SUBMITTER: Mysore K 

PROVIDER: S-EPMC8234664 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature