Pathological correlates of impaired self-awareness of memory function in Alzheimer's disease.

ABSTRACT:

Introduction

Impaired self-awareness of memory function, a.k.a. anosognosia, is a common symptom in Alzheimer's disease (AD); however, its pathological correlates remain unclear. Here, we investigated the impact of amyloid and tau on memory self-awareness.

Methods

Two hundred thirty-six clinically normal (N) and 102 impaired (I) participants from the ADNI cohort were included. Amyloid (global) and tau burden (in entorhinal and inferior temporal cortices) were assessed using positron emission tomography (PET). Self-awareness of memory was assessed using discrepancy indexes of subjective participant-informant ratings, as well as participant-objective scores of memory performance. Subjective and objective values were derived from the Everyday Cognition memory questionnaire and

SUBMITTER: Gagliardi G 

PROVIDER: S-EPMC8234669 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature