Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia.

ABSTRACT:

Background

Repeat elements constitute a large proportion of the human genome and recent evidence indicates that repeat element expression has functional roles in both physiological and pathological states. Specifically for cancer, transcription of endogenous retrotransposons is often suppressed to attenuate an anti-tumor immune response, whereas aberrant expression of heterochromatin-derived satellite RNA has been identified as a tumor driver. These insights demonstrate separate functions for the dysregulation of distinct repeat subclasses in either the attenuation or progression of human solid tumors. For hematopoietic malignancies, such as Acute Myeloid Leukemia (AML), only very few studies on the expression/dysregulation of repeat elements were done.

Methods

To study the

SUBMITTER: Onishi-Seebacher M 

PROVIDER: S-EPMC8234671 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature