Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.

ABSTRACT: Cyclase-associated proteins (CAPs) are evolutionary-conserved actin-binding proteins with crucial functions in regulating actin dynamics, the spatiotemporally controlled assembly and disassembly of actin filaments (F-actin). Mammals possess two family members (CAP1 and CAP2) with different expression patterns. Unlike most other tissues, both CAPs are expressed in the brain and present in hippocampal neurons. We recently reported crucial roles for CAP1 in growth cone function, neuron differentiation, and neuron connectivity in the mouse brain. Instead, CAP2 controls dendritic spine morphology and synaptic plasticity, and its dysregulation contributes to Alzheimer's disease pathology. These findings are in line with a model in which CAP1 controls important aspects during neuron differentiati

SUBMITTER: Schneider F 

PROVIDER: S-EPMC8234816 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature