Amphiphilic Polymer Nanoreactors for Multiple Step, One-Pot Reactions and Spontaneous Product Separation.

ABSTRACT: Performing multiple reaction steps in "one pot" to avoid the need to isolate intermediates is a promising approach for reducing solvent waste associated with liquid phase chemical processing. In this work, we incorporated gold nanoparticle catalysts into polymer nanoreactors via amphiphilic block copolymer directed self-assembly. With the polymer nanoreactors dispersed in water as the bulk solvent, we demonstrated the ability to facilitate two reaction steps in one pot with spontaneous precipitation of the product from the reaction mixture. Specifically, we achieved imide synthesis from 4-nitrophenol and benzaldehyde as a model reaction. The reaction occured in water at ambient conditions; the desired 4-benzylideneaminophenol product spontaneously precipitated from the reaction mixture whi

SUBMITTER: Harrison A 

PROVIDER: S-EPMC8234837 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature