Response Prediction and Evaluation Using PET in Patients with Solid Tumors Treated with Immunotherapy.

ABSTRACT: In multiple malignancies, checkpoint inhibitor therapy has an established role in the first-line treatment setting. However, only a subset of patients benefit from checkpoint inhibition, and as a result, the field of biomarker research is active. Molecular imaging with the use of positron emission tomography (PET) is one of the biomarkers that is being studied. PET tracers such as conventional 18F-FDG but also PD-(L)1 directed tracers are being evaluated for their predictive power. Furthermore, the use of artificial intelligence is under evaluation for the purpose of response prediction. Response evaluation during checkpoint inhibitor therapy can be challenging due to the different response patterns that can be observed compared to traditional chemotherapy. The additional information provi

SUBMITTER: Borm FJ 

PROVIDER: S-EPMC8234914 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature