Ontology highlight
ABSTRACT:
SUBMITTER: Akbulut-Jeradi N
PROVIDER: S-EPMC8234980 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Akbulut-Jeradi Nagihan N Fernandez Maria Jinky MJ Al Khaldi Rasha R Sukumaran Jalaja J Adekile Adekunle A
Journal of personalized medicine 20210617 6
Patients with sickle cell disease (SCD) in Kuwait have elevated HbF levels ranging from ~10-44%; however, the modulating factors are unclear. We investigated the association of single nucleotide polymorphisms (SNPs) at <i>BCL11A</i>, <i>HBS1L-MYB</i> and <i>HBB</i> with HbF levels in 237 Kuwaiti SCD patients, divided into 3 subgroups according to their HbF levels. Illumina Ampliseq custom DNA panel was used for genotyping and confirmed by arrayed primer extension or Sanger sequencing. In the <i> ...[more]