One-Carbon Metabolism Associated Vulnerabilities in Glioblastoma: A Review.

ABSTRACT: Altered cell metabolism is a hallmark of cancer cell biology, and the adaptive metabolic strategies of cancer cells have been of recent interest to many groups. Metabolic reprogramming has been identified as a critical step in glial cell transformation, and the use of antimetabolites against glioblastoma has been investigated. One-carbon (1-C) metabolism and its associated biosynthetic pathways, particularly purine nucleotide synthesis, are critical for rapid proliferation and are altered in many cancers. Purine metabolism has also been identified as essential for glioma tumourigenesis. Additionally, alterations of 1-C-mediated purine synthesis have been identified as commonly present in brain tumour initiating cells (BTICs) and could serve as a phenotypic marker of cells responsible for t

SUBMITTER: Ghannad-Zadeh K 

PROVIDER: S-EPMC8235277 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature