Epigenetic Silencing of MicroRNA-126 Promotes Cell Growth in Marek's Disease.

ABSTRACT: During latency, herpesvirus infection results in the establishment of a dormant state in which a restricted set of viral genes are expressed. Together with alterations of the viral genome, several host genes undergo epigenetic silencing during latency. These epigenetic dysregulations of cellular genes might be involved in the development of cancer. In this context, Gallid alphaherpesvirus 2 (GaHV-2), causing Marek's disease (MD) in susceptible chicken, was shown to impair the expression of several cellular microRNAs (miRNAs). We decided to focus on gga-miR-126, a host miRNA considered a tumor suppressor through signaling pathways controlling cell proliferation. Our objectives were to analyze the cause and the impact of miR-126 silencing during GaHV-2 infection. This cellular miRNA was foun

SUBMITTER: Gennart I 

PROVIDER: S-EPMC8235390 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature