Molecular Mechanisms during Hepatitis B Infection and the Effects of the Virus Variability.

ABSTRACT: The immunopathogenesis and molecular mechanisms involved during a hepatitis B virus (HBV) infection have made the approaches for research complex, especially concerning the patients' responses in the course of the early acute stage. The study of molecular bases involved in the viral clearance or persistence of the infection is complicated due to the difficulty to detect patients at the most adequate points of the disease, especially in the time lapse between the onset of the infection and the viral emergence. Despite this, there is valuable data obtained from animal and in vitro models, which have helped to clarify some aspects of the early immune response against HBV infection. The diversity of the HBV (genotypes and variants) has been proven to be associated not only with the development

SUBMITTER: Campos-Valdez M 

PROVIDER: S-EPMC8235420 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature