Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2.

ABSTRACT:

Background

Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine.

Methods

Blood samples from 231 subjects were collected before and 14, 28, and 42 days following coronavirus disease 2019 (COVID-19) vaccination with BNT162b2. Anti-spike receptor-binding-domain protein (anti-Spike/RBD) immunoglobulin G (IgG) antibodies were measured at each time-point. Impact of age, sex, childbearing age status, hormonal therapy, blood group, body mass index and past-history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were assessed by multivariable analyses.

Results and conclusions

In naïve subjects, the level of anti-Spike/RBD antibodies gradually increased following admini

SUBMITTER: Bayart JL 

PROVIDER: S-EPMC8235462 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature