Efficient Generation of Microdroplets Using Tail Breakup Induced with Multi-Branch Channels.

ABSTRACT: In recent years, research on the application of microdroplets in the fields of biotechnology and chemistry has made remarkable progress, but the technology for the stable generation of single-micrometer-scale microdroplets has not yet been established. In this paper, we developed an efficient and stable single-micrometer-scale droplet generation device based on the fragmentation of droplet tails, called "tail thread mode", that appears under moderate flow conditions. This method can efficiently encapsulate microbeads that mimic cells and chemical products in passively generated single-micrometer-scale microdroplets. The device has a simple 2D structure; a T-junction is used for droplet generation; and in the downstream, multi-branch channels are designed for droplet deformation into the ta

SUBMITTER: Tanaka D 

PROVIDER: S-EPMC8235478 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature