Ontology highlight
ABSTRACT:
SUBMITTER: Suresh D
PROVIDER: S-EPMC8235494 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Suresh Dittu D Sabir Shekh S Yu Tsz Tin TT Wenholz Daniel D Das Theerthankar T Black David StC DS Kumar Naresh N
Molecules (Basel, Switzerland) 20210619 12
Rottlerin is a natural product consisting of chalcone and flavonoid scaffolds, both of which have previously shown quorum sensing (QS) inhibition in various bacteria. Therefore, the unique rottlerin scaffold highlights great potential in inhibiting the QS system of <i>Pseudomonas aeruginosa.</i> Rottlerin analogues were synthesised by modifications at its chalcone- and methylene-bridged acetophenone moieties. The synthesis of analogues was achieved using an established five-step synthetic strate ...[more]