A Comprehensive Bioinformatics Analysis of Notch Pathways in Bladder Cancer.

ABSTRACT:

Background

A hallmark of Notch signaling is its variable role in tumor biology, ranging from tumor-suppressive to oncogenic effects. Until now, the mechanisms and functions of Notch pathways in bladder cancer (BCa) are still unclear.

Methods

We used publicly available data from the GTEx and TCGA-BLCA databases to explore the role of the canonical Notch pathways in BCa on the basis of the RNA expression levels of Notch receptors, ligands, and downstream genes. For statistical analyses of cancer and non-cancerous samples, we used R software packages and public databases/webservers.

Results

We found differential expression between control and BCa samples for all Notch receptors (NOTCH1, 2, 3, 4), the delta-like Notch ligands (DLL1, 3, 4), and the typical downstream gene

SUBMITTER: Zhang C 

PROVIDER: S-EPMC8235546 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature