Human amniotic mesenchymal stem cells-conditioned medium protects mice from high-fat diet-induced obesity.

ABSTRACT:

Background

Obesity is a metabolic disorder syndrome characterized by excessive fat accumulation that is related to many diseases. Human amniotic mesenchymal stem cells (hAMSCs) have a great potential for cell-based therapy due to their characteristics such as pluripotency, low immunogenicity, no tumorigenicity, potent paracrine effects, and no ethical concern. Recently, we observed that both hAMSCs and their conditioned medium (hAMSCs-CM) efficiently repaired skin injury, inhibited hepatocellular carcinoma, and alleviated high-fat diet (HFD)-induced diabetes. However, the effects and the underlying mechanisms of hAMSCs-CM on high-fat diet (HFD)-induced obesity were not explored.

Methods

The characteristics of hAMSCs were confirmed by flow cytometry, RT-PCR, and immunofluores

SUBMITTER: Tan HL 

PROVIDER: S-EPMC8235646 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature