Prolonged exposure to traffic-related particulate matter and gaseous pollutants implicate distinct molecular mechanisms of lung injury in rats.

ABSTRACT:

Background

Exposure to air pollution exerts direct effects on respiratory organs; however, molecular alterations underlying air pollution-induced pulmonary injury remain unclear. In this study, we investigated the effect of air pollution on the lung tissues of Sprague-Dawley rats with whole-body exposure to traffic-related PM₁ (particulate matter < 1 μm in aerodynamic diameter) pollutants and compared it with that in rats exposed to high-efficiency particulate air-filtered gaseous pollutants and clean air controls for 3 and 6 months. Lung function and histological examinations were performed along with quantitative proteomics analysis and functional validation.

Results

Rats in the 6-month PM₁-exposed group exhibited a significant decline in lung functio

SUBMITTER: Jheng YT 

PROVIDER: S-EPMC8235648 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature