The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression.

ABSTRACT: Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths. Metastasis is a multistage event in which cancer cells escape from the primary tumor survive in the circulation and disseminate to distant sites. According to Stephen Paget's "Seed and Soil" hypothesis, metastatic capacity is determined not only by the internal oncogenic driving force but also by the external environment of tumor cells. Throughout the body, macrophages are required for maintaining tissue homeostasis, even in the tumor milieu. To fulfill these multiple functions, macrophages are polarized from the inflammation status (M1-like) to anti-inflammation status (M2-like) to maintain the balance between inflammation and regeneration. However, tumor cell-enforced tumor-associated macrophages

SUBMITTER: Wang H 

PROVIDER: S-EPMC8235734 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature