Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia.

ABSTRACT: Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic components. While reduced midbrain GABAergic inhibitory neurotransmission may contribute to the hyperdopaminergia thought to underpin psychosis in schizophrenia, molecular changes consistent with this have not been reported. We hypothesised that reduced GABA-related molecular markers would be found in the midbrain of people with schizophrenia and that these would correlate with dopaminergic molecular changes. We hypothesised that downregulation of inhibitory neuron markers would be exacerbated in schizophrenia cases with high levels of neuroinflammation. Eight GABAergic-related transcripts were measured with quantitative PCR, and glutamate decarb

SUBMITTER: Purves-Tyson TD 

PROVIDER: S-EPMC8235806 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature