Breast cancer risk factors in relation to molecular subtypes in breast cancer patients from Kenya.

ABSTRACT:

Background

Few studies have investigated risk factor heterogeneity by molecular subtypes in indigenous African populations where prevalence of traditional breast cancer (BC) risk factors, genetic background, and environmental exposures show marked differences compared to European ancestry populations.

Methods

We conducted a case-only analysis of 838 pathologically confirmed BC cases recruited from 5 groups of public, faith-based, and private institutions across Kenya between March 2012 to May 2015. Centralized pathology review and immunohistochemistry (IHC) for key markers (ER, PR, HER2, EGFR, CK5-6, and Ki67) was performed to define subtypes. Risk factor data was collected at time of diagnosis through a questionnaire. Multivariable polytomous logistic regression models were

SUBMITTER: Sayed S 

PROVIDER: S-EPMC8235821 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature