OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation.

ABSTRACT:

Background

Oligodendrocytes, responsible for axon ensheathment, are critical for central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development and performs distinct functions at different stages. Previous studies have shown that lncRNAs (long non-coding RNAs; > 200 bp) have important functions during oligodendrocyte development, but their roles have not been systematically characterized and their regulation is not yet clear.

Results

We performed an integrated study of genome-wide OLIG2 binding and the epigenetic modification status of both coding and non-coding genes during three stages of oligodendrocyte differentiation in vivo: neural stem cells (NSCs), oligodendrocyte progenit

SUBMITTER: Wei H 

PROVIDER: S-EPMC8235854 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature