Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study.

ABSTRACT:

Introduction

Oxytocin is a key mediator of emotional and social behavior that seems to be of relevance for the development and maintenance of addictive behaviors. We thus investigated the effect of oxytocin on neural response and behavior during a face-matching task in a sample of social drinkers.

Methods

Thirteen social drinkers underwent a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging face-matching task with and without prior intranasal application of 24 international units oxytocin. Effects of oxytocin and task condition (faces, shapes) on brain activation and individual task performance were assessed.

Results

Face-matching compared to shape-matching trials resulted in higher brain activation in the bilateral amygdala,

SUBMITTER: Bach P 

PROVIDER: S-EPMC8236029 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature