Factor VIII replacement prophylaxis in patients with hemophilia A transitioning to adults: a systematic literature review.

ABSTRACT:

Background

Despite the advantages of prophylactic treatment for hemophilia, patients tend to discontinue or not adhere to it because of several challenges such as long-term use, high cost, young patients transitioning to adolescents, and switch to self-infusion or self-care. The goal of this systematic literature review is to emphasize adherence to and efficiency of prophylactic treatment in adults.

Methods

A literature review was conducted in PubMed, Embase, and Cochrane databases until April 2021 according to PRISMA guidelines, and the protocol was registered with PROSPERO (CRD42020220085). Studies evaluating the efficacy of prophylaxis in enhancing the quality of life were included.

Results

A total of 31 articles involving 2379 patients with hemophilia were include

SUBMITTER: Sun J 

PROVIDER: S-EPMC8236177 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature