Clinicopathologic features of TDO2 overexpression in renal cell carcinoma.

ABSTRACT:

Background

Tryptophan 2,3-dioxygenase (TDO2) is the primary enzyme catabolizing tryptophan. Several lines of evidence revealed that overexpression of TDO2 is involved in anoikis resistance, spheroid formation, proliferation, and invasion and correlates with poor prognosis in some cancers. The aim of this research was to uncover the expression and biofunction of TDO2 in renal cell carcinoma (RCC).

Methods

To show the expression of TDO2 in RCC, we performed qRT-PCR and immunohistochemistry in integration with TCGA data analysis. The interaction of TDO2 with PD-L1, CD44, PTEN, and TDO2 expression was evaluated. We explored proliferation, colony formation, and invasion in RCC cells line affected by knockdown of TDO2.

Results

RNA-Seq and immunohistochemical analysis showed

SUBMITTER: Pham QT 

PROVIDER: S-EPMC8236178 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature