Bioinformatics analysis of differentially expressed genes and pathways in the development of cervical cancer.

ABSTRACT:

Background

This study aimed to explore and identify key genes and signaling pathways that contribute to the progression of cervical cancer to improve prognosis.

Methods

Three gene expression profiles (GSE63514, GSE64217 and GSE138080) were screened and downloaded from the Gene Expression Omnibus database (GEO). Differentially expressed genes (DEGs) were screened using the GEO2R and Venn diagram tools. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Gene set enrichment analysis (GSEA) was performed to analyze the three gene expression profiles. Moreover, a protein-protein interaction (PPI) network of the DEGs was constructed, and functional enrichment analysis was performed. On this basis, hub genes from

SUBMITTER: Wu B 

PROVIDER: S-EPMC8236200 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature