Detecting cord blood cell type-specific epigenetic associations with gestational diabetes mellitus and early childhood growth.

ABSTRACT:

Background

Epigenome-wide association studies (EWAS) have provided opportunities to understand the role of epigenetic mechanisms in development and pathophysiology of many chronic diseases. However, an important limitation of conventional EWAS is that profiles of epigenetic variability are often obtained in samples of mixed cell types. Here, we aim to assess whether changes in cord blood DNA methylation (DNAm) associated with gestational diabetes mellitus (GDM) exposure and early childhood growth markers occur in a cell type-specific manner.

Results

We analyzed 275 cord blood samples collected at delivery from a prospective pre-birth cohort with genome-wide DNAm profiled by the Illumina MethylationEPIC array. We estimated proportions of seven common cell types in each sample

SUBMITTER: Lu T 

PROVIDER: S-EPMC8236204 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature