Extensive weight loss reduces glycan age by altering IgG N-glycosylation.

ABSTRACT:

Background

Obesity, a major global health problem, is associated with increased cardiometabolic morbidity and mortality. Protein glycosylation is a frequent posttranslational modification, highly responsive to inflammation and ageing. The prospect of biological age reduction, by changing glycosylation patterns through metabolic intervention, opens many possibilities. We have investigated whether weight loss interventions affect inflammation- and ageing-associated IgG glycosylation changes, in a longitudinal cohort of bariatric surgery patients. To support potential findings, BMI-related glycosylation changes were monitored in a longitudinal twins cohort.

Methods

IgG N-glycans were chromatographically profiled in 37 obese patients, subjected to low-calorie diet, followed by b

SUBMITTER: Greto VL 

PROVIDER: S-EPMC8236401 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature