Temporal relationship between body mass index and uric acid and their joint impact on blood pressure in children and adults: the Bogalusa Heart Study.

ABSTRACT:

Objective

This study aimed to examine the temporal relationship between body mass index (BMI) and uric acid (UA), and their joint effect on blood pressure (BP) in children and adults.

Methods

The longitudinal cohorts for temporal relationship analyses consisted of 564 and 911 subjects examined twice 5-14 years apart from childhood to adulthood. The cross-sectional cohorts for mediation analyses consisted of 3102 children and 3402 nondiabetic adults. Cross-lagged panel analysis models were used to examine the temporal relationship between BMI and UA, and mediation analysis models the mediation effect of UA on the BMI-BP association.

Results

After adjusting for age, race, sex and follow-up years in children, and additionally smoking and alcohol drinking in adults, the p

SUBMITTER: Yun M 

PROVIDER: S-EPMC8236402 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature