Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice.

ABSTRACT:

Background/objectives

Translationally controlled tumor protein (TCTP) exhibits numerous biological functions. It has been shown to be involved in the regulation of glucose. However, its specific role in metabolism has not yet been clearly elucidated. Here, we aimed to assess the effect of TCTP overexpression on metabolic tissues and systemic energy metabolism.

Subjects/methods

We investigated whether TCTP can ameliorate the metabolic imbalance that causes obesity using TCTP-overexpressing transgenic (TCTP TG) mice. The mice were subjected to biochemical, morphological, physiological and protein expression studies to define the role of TCTP in metabolic regulation in response to normal chow diet (NCD) compared to high-fat diet (HFD) conditions, and cold environment.

Result

SUBMITTER: Jeon Y 

PROVIDER: S-EPMC8236403 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature