Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution.

ABSTRACT:

Background

Evidence from in vitro and rodent studies suggests that leptin, a key signal of long-term energy reserves, promotes IGF1 synthesis and linear growth. This effect of leptin has not been fully investigated in humans. The aim of our study was to investigate the effect of leptin substitution on growth factors and linear growth in children with congenital leptin deficiency (CLD).

Methods

In this cohort study we included eight pediatric patients (six males), age 0.9-14.8 years, who were diagnosed with CLD and received leptin substitution at our University Medical Center. We calculated standard deviation scores (SDS) for serum levels of IGF1 and IGFBP3, IGF1/IGFBP3 molar ratio, and height at baseline (T0) and 12 months (T12) after the initiation of substitution with metr

SUBMITTER: Beghini M 

PROVIDER: S-EPMC8236407 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature