Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer.

ABSTRACT: Chronic stress leads to the activation of the beta-adrenergic pathway. Its activation has been implicated in the progression of different types of cancer but its role on head and neck squamous cell carcinomas (HNSCCs) remains undefined. The aim of this study was to investigate the influence of the beta-adrenergic pathway activation in the progression of HNSCCs and offer a panel of potential treatments for patients with the active beta-adrenergic pathway. Five hundred and twenty TCGA patients with primary HNSCCs were divided in two groups: ADRB2^low / SLC6A2^low and ADRB2^high / SLC6A2^high. Differentially expressed genes (DEGs) were identified through differential expression analysis. The association of clinicopathological and genomic features betwee

SUBMITTER: Lopes-Santos G 

PROVIDER: S-EPMC8236611 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature