Construction of Two Alternative Polyadenylation Signatures to Predict the Prognosis of Sarcoma Patients.

ABSTRACT:

Background

Increasing evidence indicates that alternative polyadenylation (APA) is associated with the prognosis of cancers.

Methods

We obtained gene expression and APA profiles of 259 sarcoma patients from the TCGA dataportal and TC3A database, respectively. The prognostic signatures, clinical nomograms, and regulatory networks were studied by integrated bioinformatics analyses. Then, the immune cell infiltration profile was obtained from the ImmuCellAI. The association between APA-based signature and immune cells was studied.

Results

A total of 61 and 38 APA events were identified as overall survival (OS)- and progress free-survival (PFS)-related biomarkers, respectively. Two signatures were generated. The area under the curves (AUC) values of OS signature were 0.90

SUBMITTER: Hu C 

PROVIDER: S-EPMC8236624 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature