Impairment of Cyclo-oxygenase-2 Function Results in Abnormal Growth Plate Development and Bone Microarchitecture but Does Not Affect Longitudinal Growth of the Long Bones in Skeletally Immature Mice.

ABSTRACT:

Objective

Despite the general awareness that cyclo-oxygenase-2 (COX-2) is crucial for endochondral ossification, the role of COX-2 in skeletal development is largely unknown. We hypothesized that inhibition or genetic loss of COX-2 leads to impaired growth plate development and consequently impaired postnatal development of the long bones.

Design

Skeletally immature (5 weeks old) B6;129S-Ptgs2^tm1Jed/J wildtype mice were treated for 10 weeks with celecoxib (daily oral administration 10 mg/kg) or placebo and compared with B6;129S-Ptgs2^tm1Jed/J homozygous knockout mice (n = 12 per group).

Results

Fifteen weeks postnatally, no significant difference in growth plate (zone) thickness was found between groups. However, significantly higher proteo

SUBMITTER: Caron MMJ 

PROVIDER: S-EPMC8236650 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature