High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.

ABSTRACT:

Purpose

Two-year follow-up to assess efficacy and safety of high-density autologous chondrocyte implantation (HD-ACI) in patients with cartilage lesions in the ankle.

Design

Twenty-four consecutive patients with International Cartilage repair Society (ICRS) grade 3-4 cartilage lesions of the ankle were included. Five million chondrocytes per cm² of lesion were implanted using a type I/III collagen membrane as a carrier and treatment effectiveness was assessed by evaluating pain with the visual analogue scale (VAS) and American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score at baseline, 12-month, and 24-month follow-up, together with dorsal and plantar flexion. Magnetic resonance observation for cartilage repair tissue (MOCART) score was used to eval

SUBMITTER: Lopez-Alcorocho JM 

PROVIDER: S-EPMC8236657 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature