Mast Cells Modulate Antigen-Specific CD8⁺ T Cell Activation During LCMV Infection.

ABSTRACT: Mast cells (MCs), strategically localized at mucosal surfaces, provide first-line defense against pathogens and shape innate and adaptive immune responses. Recent studies have shown that MCs are involved in pathogenic responses to several viruses including herpes simplex viruses, dengue virus, vaccinia virus and influenza virus. However, the underlying mechanisms of MCs in the activation of CD8⁺ T cells during viral infections are not fully understood. Therefore, we investigate the role of MCs in the development of virus-specific CD8⁺ T cell responses using the well-characterized murine lymphocytic choriomeningitis virus (LCMV) model and the transgenic MasTRECK mice that contain the human diphtheria toxin receptor as an inducible MC-deficient model. Here, we report th

SUBMITTER: Hackler Y 

PROVIDER: S-EPMC8236703 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature