Highly prevalent Russian HIV-1 V3-loop sequence variants are susceptible to maraviroc.

ABSTRACT:

Introduction

Maraviroc inhibits CCR5-tropic HIV-1 across different subtypes in vitro and has demonstrated efficacy in clinical trials. V3-loop amino acid variants observed in individual maraviroc-resistant viruses have not been found to be predictive of reduced susceptibility. Sequence-database searches have demonstrated that approximately 7.3% of viruses naturally encode these variants, raising concerns regarding potential pre-existing resistance. A study from Russia reported that combinations of these same amino acids are present in the V3 loops of the Russian variant subtype A (IDU-A, now A6) with a much greater prevalence (range: 74.4%-92.3%) depending on the combination. However, these studies and database searches did not include phenotypic evaluation.

Methods

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SUBMITTER: Lewis ME 

PROVIDER: S-EPMC8236768 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature