A prospective, observational study of fidaxomicin use for Clostridioides difficile infection in France.

ABSTRACT:

Objective

To describe the characteristics, management and outcomes of hospitalised patients with Clostridioides difficile infection (CDI) treated with and without fidaxomicin.

Methods

This prospective, multicentre, observational study (DAFNE) enrolled hospitalised patients with CDI, including 294 patients treated with fidaxomicin (outcomes recorded over a 3-month period) and 150 patients treated with other CDI therapies during three 1-month periods. The primary endpoint was baseline and CDI characteristics of fidaxomicin-treated patients.

Results

At baseline, the fidaxomicin-treated population included immunocompromised patients (39.1%) and patients with severe (59.2%) and recurrent (36.4%) CDI. Fidaxomicin was associated with a high rate of clinical cure (92.2

SUBMITTER: Guery B 

PROVIDER: S-EPMC8236878 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature