The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review.

ABSTRACT: Background: Adverse drug reactions (ADR) are a major clinical problem accounting for significant hospital admission rates, morbidity, mortality, and health care costs. One-third of people with diabetes experience at least one ADR. However, there is notable interindividual heterogeneity resulting in patient harm and unnecessary medical costs. Genomics is at the forefront of research to understand interindividual variability, and there are many genotype-drug response associations in diabetes with inconsistent findings. Here, we conducted a systematic review to comprehensively examine and synthesize the effect of genetic polymorphisms on the incidence of ADRs of oral glucose-lowering drugs in people with type 2 diabetes. Methods: A literature search was made to identify articles

SUBMITTER: Baye AM 

PROVIDER: S-EPMC8236944 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature