Identification of Regulatory Functions of LncRNAs Associated With T. circumcincta Infection in Adult Sheep.

ABSTRACT: Several recent studies have demonstrated the role of long non-coding RNAs (lncRNAs) in regulating the defense mechanism against parasite infections, but no studies are available that investigated their relevance for immune response to nematode infection in sheep. Thus, the aim of the current study was to (i) detect putative lncRNAs that are expressed in the abomasal lymph node of adult sheep after an experimental infection with the gastrointestinal nematode (GIN) Teladorsagia circumcincta and (ii) to elucidate their potential functional role associated with the differential host immune response. We hypothesized that putative lncRNAs differentially expressed (DE) between samples from animals that differ in resistance to infection may play a significant regulatory role in response to

SUBMITTER: Chitneedi PK 

PROVIDER: S-EPMC8236958 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature