Proteomic and metabolomic investigation of serum lactate dehydrogenase elevation in COVID-19 patients.

ABSTRACT: Serum lactate dehydrogenase (LDH) has been established as a prognostic indicator given its differential expression in COVID-19 patients. However, the molecular mechanisms underneath remain poorly understood. In this study, 144 COVID-19 patients were enrolled to monitor the clinical and laboratory parameters over 3 weeks. Serum LDH was shown elevated in the COVID-19 patients on admission and declined throughout disease course, and its ability to classify patient severity outperformed other biochemical indicators. A threshold of 247 U/L serum LDH on admission was determined for severity prognosis. Next, we classified a subset of 14 patients into high- and low-risk groups based on serum LDH expression and compared their quantitative serum proteomic and metabolomic differences. The results sho

SUBMITTER: Yan H 

PROVIDER: S-EPMC8237019 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature