Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome.

ABSTRACT:

Backgrounds

Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown.

Methods

We retrospectively enrolled participants in health screening programs at three hospitals from 1995 to 2009. We defined two different participant groups as YR1 and YR3, which had available 1-year or 3-year eGFR values along with their baseline eGFR levels. We compared the effectiveness of eGFR percentage change or slope to estimate end-stage renal disease (ESRD) risk according to two estimating equations (modified Modification of Diet in Renal Disea

SUBMITTER: Kim K 

PROVIDER: S-EPMC8237122 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature