Integrative Characterization of Immune-relevant Genes in Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

Tumor microenvironment plays an essential role in cancer development and progression. Cancer immunotherapy has become a promising approach for the treatment of hepatocellular carcinoma (HCC). We aimed to analyze the HCC immune microenvironment characteristics to identify immune-related genetic changes.

Methods

Key immune-relevant genes (KIRGs) were obtained through integrating the differentially expressed genes of The Cancer Genome Atlas, immune genes from the Immunology Database and Analysis Portal, and immune differentially expressed genes determined by single-sample gene set enrichment analysis scores. Cox regression analysis was performed to mine therapeutic target genes. A regulatory network based on KIRGs, transcription factors, and immune-related l

SUBMITTER: Hong WF 

PROVIDER: S-EPMC8237144 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature