Hypotension in Preterm Infants (HIP) randomised trial.

ABSTRACT:

Objective

To determine whether restricting the use of inotrope after diagnosis of low blood pressure (BP) in the first 72 hours of life affects survival without significant brain injury at 36 weeks of postmenstrual age (PMA) in infants born before 28 weeks of gestation.

Design

Double-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.

Setting

10 sites across Europe and Canada.

Participants

Infants born before 28 weeks of gestation were eligible if they had an invasive mean BP less than their gestational age that persisted for ≥15 min in the first 72 hours of life and a cerebral ultrasound free of significant (≥ grade 3) intraventricular haemorrhage.

Intervention

Participants were randomly assigned to saline bolus follo

SUBMITTER: Dempsey EM 

PROVIDER: S-EPMC8237176 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature